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Notably, the proposed binding mode is compatible with the simultaneous binding of the substrate L-Leu- p NA, in agreement with the uncompetitive IRAP inhibition determined for a representative compound

a c ) Representative images of TH immunofluorescence of the whole SNc/VTA brain region from Trkb Penk-WT control ( a ), Trkb Penk-KO mutant injected with Gsto2 -shRNA ( b ) or scrambled-shRNA ( c ) in the striatum at 3 M

At the same time, his supporters make an equally compelling case